New South Wales pulled off the largest comeback in State of Origin, overcoming a 20-point deficit to win 22-20 at Stadium Australia in Sydney.
Queensland raced out to a 20-0 lead in the first half, and led 20-6 at half-time.
But the defining moment of the match came in the 57th minute when Maroons fullback Kalyn Ponga was sent off for a shoulder charge that made contact with the head of Blues winger Tolutau Koula.
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The visitors were down to 12 men for the remaining 23 minutes, desperately trying to hold on to their 14-point lead.
But the Blues would score three tries, including a stunning individual effort from fullback James Tedesco in the 79th minute, to steal the win.